MovDisordV3, Main, Exploration, bibRecord, 000863

Parkinson Disease Phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations

Identifieur interne : 000863 ( Main/Exploration ); précédent : 000862; suivant : 000864

Parkinson Disease Phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations

Auteurs : Roy N. Alcalay [États-Unis] ; Anat Mirelman [Israël] ; Rachel Saunders-Pullman [États-Unis] ; Ming-X Tang [États-Unis] ; Helen Mejia Santana [États-Unis] ; Deborah Raymond [États-Unis] ; Ernest Roos [États-Unis] ; Martha Orbe-Reilly [États-Unis] ; Tanya Gurevich [Israël] ; Anat Bar Shira [Israël] ; Mali Gana Weisz [Israël] ; Kira Yasinovsky [États-Unis] ; Maayan Zalis [Israël] ; Avner Thaler [Israël] ; Andres Deik [États-Unis] ; Matthew James Barrett [États-Unis] ; Jose Cabassa [États-Unis] ; Mark Groves [États-Unis] ; Ann L. Hunt [États-Unis] ; Naomi Lubarr [États-Unis] ; Marta San Luciano [États-Unis] ; Joan Miravite [États-Unis] ; Christina Palmese [États-Unis] ; Rivka Sachdev [États-Unis] ; Harini Sarva [États-Unis] ; Lawrence Severt [États-Unis] ; Vicki Shanker [États-Unis] ; Matthew Carrington Swan [États-Unis] ; Jeannie Soto-Valencia [États-Unis] ; Brooke Johannes [États-Unis] ; Robert Ortega [États-Unis] ; Stanley Fahn [États-Unis] ; Lucien Cote [États-Unis] ; Cheryl Waters [États-Unis] ; Pietro Mazzoni [États-Unis] ; Blair Ford [États-Unis] ; Elan Louis [États-Unis] ; Oren Levy [États-Unis] ; Llency Rosado [États-Unis] ; Diana Ruiz [États-Unis] ; Tsvyatko Dorovski [États-Unis] ; Michael Pauciulo ; William Nichols ; Avi Orr-Urtreger [Israël] ; Laurie Ozelius ; Lorraine Clark [États-Unis] ; Nir Giladi [Israël] ; Susan Bressman [États-Unis] ; Karen S. Marder [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:3859844

English descriptors

KwdEn :
- Aged, Female, Genotype, Glycine (genetics), Humans, Jews (genetics), Male, Middle Aged, Mutation (genetics), Parkinson Disease (ethnology), Parkinson Disease (genetics), Phenotype, Protein-Serine-Threonine Kinases (genetics), Questionnaires, Regression Analysis, Serine (genetics), Severity of Illness Index.
MESH :
- chemical , genetics : Glycine, Protein-Serine-Threonine Kinases, Serine.
- ethnology : Parkinson Disease.
- genetics : Jews, Mutation, Parkinson Disease.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Phenotype, Questionnaires, Regression Analysis, Severity of Illness Index.

Abstract

Background

The phenotype of Parkinson disease (PD) patients with and without LRRK2 G2019S mutations is reported to be similar; however large uniformly evaluated series are lacking.

Objective

To characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation.

Methods

We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). GBA mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the geriatric depression scale (GDS) and the non-motor symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and LRRK2 status (outcome) in 488 newly recruited participants.

Results

LRRK2 G2019S carriers (n=97) and non-carriers (n=391) were similar in age and age-at-onset of PD. Carriers had longer disease duration (8.6years versus 6.1years, p<0.001), were more likely to be women (51.5% versus 37.9%, p=0.015) and more often reported first symptoms in lower extremities (40.0% versus 19.2%, p<0.001). In logistic models adjusted for age, disease duration, gender, education, and site, carriers were more likely to have lower extremity onset (p<0.001), postural instability gait difficulty (PIGD, p=0.043) and persistent levodopa response for>5 years (p=0.042). Performance on UPDRS, MoCA, GDS and NMS did not differ by mutation status.

Conclusion

PD in AJ-LRRK2 G2019S mutation carriers is similar to idiopathic PD, but characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859844

DOI: 10.1002/mds.25647
PubMed: 24243757
PubMed Central: 3859844

Affiliations:

Le document en format XML

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 G2019S mutations</title>
<author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
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<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
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<author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
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<affiliation wicri:level="1"><nlm:aff id="A4"> School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> School of Health Related Professions, Ben Gurion University, Beer Sheba</wicri:regionArea>
<wicri:noRegion>Beer Sheba</wicri:noRegion>
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<author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
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<author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name>
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<author><name sortKey="Santana, Helen Mejia" sort="Santana, Helen Mejia" uniqKey="Santana H" first="Helen Mejia" last="Santana">Helen Mejia Santana</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
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<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
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</author>
<author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shira, Anat Bar" sort="Shira, Anat Bar" uniqKey="Shira A" first="Anat Bar" last="Shira">Anat Bar Shira</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisz, Mali Gana" sort="Weisz, Mali Gana" uniqKey="Weisz M" first="Mali Gana" last="Weisz">Mali Gana Weisz</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L." last="Hunt">Ann L. Hunt</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luciano, Marta San" sort="Luciano, Marta San" uniqKey="Luciano M" first="Marta San" last="Luciano">Marta San Luciano</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name>
<affiliation wicri:level="4"><nlm:aff id="A9"> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name>
<affiliation><nlm:aff id="A10"> Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">University of Cincinnati College of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name>
<affiliation><nlm:aff id="A10"> Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">University of Cincinnati College of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name>
<affiliation><nlm:aff id="A11"> Departments of Genetics and Genomic Sciences and Neurology, Mount Sinai School of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">Mount Sinai School of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name>
<affiliation wicri:level="4"><nlm:aff id="A12"> Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A13"> Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A9"> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A14"> Department of Psychiatry, Columbia University Medical Center, NYC, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Psychiatry, Columbia University Medical Center, NYC, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">24243757</idno>
<idno type="pmc">3859844</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859844</idno>
<idno type="RBID">PMC:3859844</idno>
<idno type="doi">10.1002/mds.25647</idno>
<date when="2013">2013</date>
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<idno type="wicri:Area/Pmc/Curation">000371</idno>
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<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000676</idno>
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<idno type="wicri:Area/Ncbi/Checkpoint">003E21</idno>
<idno type="wicri:doubleKey">0885-3185:2013:Alcalay R:parkinson:disease:phenotype</idno>
<idno type="wicri:Area/Main/Merge">000863</idno>
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<idno type="wicri:Area/Main/Exploration">000863</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkinson Disease Phenotype in Ashkenazi Jews with and without <italic>LRRK2</italic>
 G2019S mutations</title>
<author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4"> School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> School of Health Related Professions, Ben Gurion University, Beer Sheba</wicri:regionArea>
<wicri:noRegion>Beer Sheba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Santana, Helen Mejia" sort="Santana, Helen Mejia" uniqKey="Santana H" first="Helen Mejia" last="Santana">Helen Mejia Santana</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shira, Anat Bar" sort="Shira, Anat Bar" uniqKey="Shira A" first="Anat Bar" last="Shira">Anat Bar Shira</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisz, Mali Gana" sort="Weisz, Mali Gana" uniqKey="Weisz M" first="Mali Gana" last="Weisz">Mali Gana Weisz</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L." last="Hunt">Ann L. Hunt</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luciano, Marta San" sort="Luciano, Marta San" uniqKey="Luciano M" first="Marta San" last="Luciano">Marta San Luciano</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name>
<affiliation wicri:level="4"><nlm:aff id="A9"> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name>
<affiliation><nlm:aff id="A10"> Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">University of Cincinnati College of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name>
<affiliation><nlm:aff id="A10"> Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">University of Cincinnati College of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetics Institute, Tel Aviv Sourasky Medical Center, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Genetics Institute, Tel Aviv Sourasky Medical Center</wicri:regionArea>
<wicri:noRegion>Tel Aviv Sourasky Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name>
<affiliation><nlm:aff id="A11"> Departments of Genetics and Genomic Sciences and Neurology, Mount Sinai School of Medicine.</nlm:aff>
<wicri:noCountry code="subfield">Mount Sinai School of Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name>
<affiliation wicri:level="4"><nlm:aff id="A12"> Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A13"> Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7"> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation wicri:level="2"><nlm:aff id="A5"> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A9"> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A14"> Department of Psychiatry, Columbia University Medical Center, NYC, NY, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Psychiatry, Columbia University Medical Center, NYC, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Genotype</term>
<term>Glycine (genetics)</term>
<term>Humans</term>
<term>Jews (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Parkinson Disease (ethnology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Phenotype</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Questionnaires</term>
<term>Regression Analysis</term>
<term>Serine (genetics)</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycine</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Serine</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Jews</term>
<term>Mutation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phenotype</term>
<term>Questionnaires</term>
<term>Regression Analysis</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The phenotype of Parkinson disease (PD) patients with and without <italic>LRRK2</italic>
 G2019S mutations is reported to be similar; however large uniformly evaluated series are lacking.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">To characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the <italic>LRRK2</italic>
 G2019S mutation.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). <italic>GBA</italic>
 mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the geriatric depression scale (GDS) and the non-motor symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and <italic>LRRK2</italic>
 status (outcome) in 488 newly recruited participants.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4"><italic>LRRK2</italic>
 G2019S carriers (n=97) and non-carriers (n=391) were similar in age and age-at-onset of PD. Carriers had longer disease duration (8.6years versus 6.1years, p<0.001), were more likely to be women (51.5% versus 37.9%, p=0.015) and more often reported first symptoms in lower extremities (40.0% versus 19.2%, p<0.001). In logistic models adjusted for age, disease duration, gender, education, and site, carriers were more likely to have lower extremity onset (p<0.001), postural instability gait difficulty (PIGD, p=0.043) and persistent levodopa response for>5 years (p=0.042). Performance on UPDRS, MoCA, GDS and NMS did not differ by mutation status.</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">PD in AJ-<italic>LRRK2</italic>
 G2019S mutation carriers is similar to idiopathic PD, but characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Israël</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
<settlement><li>New York</li>
</settlement>
<orgName><li>Université Columbia</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Nichols, William" sort="Nichols, William" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name>
<name sortKey="Ozelius, Laurie" sort="Ozelius, Laurie" uniqKey="Ozelius L" first="Laurie" last="Ozelius">Laurie Ozelius</name>
<name sortKey="Pauciulo, Michael" sort="Pauciulo, Michael" uniqKey="Pauciulo M" first="Michael" last="Pauciulo">Michael Pauciulo</name>
</noCountry>
<country name="États-Unis"><region name="État de New York"><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name>
</region>
<name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name>
<name sortKey="Barrett, Matthew James" sort="Barrett, Matthew James" uniqKey="Barrett M" first="Matthew James" last="Barrett">Matthew James Barrett</name>
<name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<name sortKey="Cabassa, Jose" sort="Cabassa, Jose" uniqKey="Cabassa J" first="Jose" last="Cabassa">Jose Cabassa</name>
<name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name>
<name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name>
<name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name>
<name sortKey="Deik, Andres" sort="Deik, Andres" uniqKey="Deik A" first="Andres" last="Deik">Andres Deik</name>
<name sortKey="Dorovski, Tsvyatko" sort="Dorovski, Tsvyatko" uniqKey="Dorovski T" first="Tsvyatko" last="Dorovski">Tsvyatko Dorovski</name>
<name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name>
<name sortKey="Groves, Mark" sort="Groves, Mark" uniqKey="Groves M" first="Mark" last="Groves">Mark Groves</name>
<name sortKey="Hunt, Ann L" sort="Hunt, Ann L" uniqKey="Hunt A" first="Ann L." last="Hunt">Ann L. Hunt</name>
<name sortKey="Johannes, Brooke" sort="Johannes, Brooke" uniqKey="Johannes B" first="Brooke" last="Johannes">Brooke Johannes</name>
<name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name>
<name sortKey="Levy, Oren" sort="Levy, Oren" uniqKey="Levy O" first="Oren" last="Levy">Oren Levy</name>
<name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name>
<name sortKey="Louis, Elan" sort="Louis, Elan" uniqKey="Louis E" first="Elan" last="Louis">Elan Louis</name>
<name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name>
<name sortKey="Lubarr, Naomi" sort="Lubarr, Naomi" uniqKey="Lubarr N" first="Naomi" last="Lubarr">Naomi Lubarr</name>
<name sortKey="Luciano, Marta San" sort="Luciano, Marta San" uniqKey="Luciano M" first="Marta San" last="Luciano">Marta San Luciano</name>
<name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
<name sortKey="Mazzoni, Pietro" sort="Mazzoni, Pietro" uniqKey="Mazzoni P" first="Pietro" last="Mazzoni">Pietro Mazzoni</name>
<name sortKey="Miravite, Joan" sort="Miravite, Joan" uniqKey="Miravite J" first="Joan" last="Miravite">Joan Miravite</name>
<name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe-Reilly">Martha Orbe-Reilly</name>
<name sortKey="Ortega, Robert" sort="Ortega, Robert" uniqKey="Ortega R" first="Robert" last="Ortega">Robert Ortega</name>
<name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name>
<name sortKey="Palmese, Christina" sort="Palmese, Christina" uniqKey="Palmese C" first="Christina" last="Palmese">Christina Palmese</name>
<name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name>
<name sortKey="Roos, Ernest" sort="Roos, Ernest" uniqKey="Roos E" first="Ernest" last="Roos">Ernest Roos</name>
<name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name>
<name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name>
<name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name>
<name sortKey="Sachdev, Rivka" sort="Sachdev, Rivka" uniqKey="Sachdev R" first="Rivka" last="Sachdev">Rivka Sachdev</name>
<name sortKey="Santana, Helen Mejia" sort="Santana, Helen Mejia" uniqKey="Santana H" first="Helen Mejia" last="Santana">Helen Mejia Santana</name>
<name sortKey="Sarva, Harini" sort="Sarva, Harini" uniqKey="Sarva H" first="Harini" last="Sarva">Harini Sarva</name>
<name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name>
<name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name>
<name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name>
<name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name>
<name sortKey="Shanker, Vicki" sort="Shanker, Vicki" uniqKey="Shanker V" first="Vicki" last="Shanker">Vicki Shanker</name>
<name sortKey="Soto Valencia, Jeannie" sort="Soto Valencia, Jeannie" uniqKey="Soto Valencia J" first="Jeannie" last="Soto-Valencia">Jeannie Soto-Valencia</name>
<name sortKey="Swan, Matthew Carrington" sort="Swan, Matthew Carrington" uniqKey="Swan M" first="Matthew Carrington" last="Swan">Matthew Carrington Swan</name>
<name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name>
<name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name>
<name sortKey="Yasinovsky, Kira" sort="Yasinovsky, Kira" uniqKey="Yasinovsky K" first="Kira" last="Yasinovsky">Kira Yasinovsky</name>
</country>
<country name="Israël"><noRegion><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name>
</noRegion>
<name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name>
<name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name>
<name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name>
<name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name>
<name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name>
<name sortKey="Shira, Anat Bar" sort="Shira, Anat Bar" uniqKey="Shira A" first="Anat Bar" last="Shira">Anat Bar Shira</name>
<name sortKey="Thaler, Avner" sort="Thaler, Avner" uniqKey="Thaler A" first="Avner" last="Thaler">Avner Thaler</name>
<name sortKey="Weisz, Mali Gana" sort="Weisz, Mali Gana" uniqKey="Weisz M" first="Mali Gana" last="Weisz">Mali Gana Weisz</name>
<name sortKey="Zalis, Maayan" sort="Zalis, Maayan" uniqKey="Zalis M" first="Maayan" last="Zalis">Maayan Zalis</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Parkinson Disease Phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations

Parkinson Disease Phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations

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	Movement Disorders (revue)
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